Multiple Myeloma & Amyloidosis Program
Symptoms of Multiple Myeloma
Cancerous plasma cells produce abnormal proteins which cause tissue damage. The signs and symptoms can vary and sometimes, early on, there may be none.
If they do occur, the symptoms can include:
- Calcium elevation
- Renal insufficiency
- Anemia
- Bone abnormalities
- Bone pain and/or skeletal fractures
- Fatigue and weakness
- Frequent infections (caused by a weak immune system).
Always see your doctor if you notice any ongoing signs or symptoms that you are worried about.
Doctors aren’t sure what causes multiple myeloma, but they know that it begins with an abnormal plasma cell within your bone marrow. Over time, they accumulate and produce abnormal antibodies, (called monoclonal proteins, or M proteins) which the body can’t use, leading to problems such as damage to the bones or kidneys.
Multiple myeloma usually begins as a condition called monoclonal gammopathy of undetermined significance (MGUS). This is marked by the presence of M proteins, but in MGUS they do not cause damage to the body.
Symptoms of Amyloidosis
Symptoms will depend on the organ involved. It may present with symptoms of:
- Heart failure
- Kidney failure
- Abnormal blood pressure
- Racoon eyes (bruising which appears as dark circles around the eyes)
- and others.
Causes & Risk Factors of Multiple Myeloma and Amyloidosis
Other risk factors can include:
- Age: Risk increases in those over 50.
- Gender: Men are more at risk.
- Race: People with black skin are more at risk.
- Obesity: Being overweight can increase risk.
- Chronic Immunodeficiency.
- Inflammatory Diseases: Conditions such as cardiovascular disease or type 2 diabetes may increase risk.
Prevention & Screening
Doctors believe that very few cases of myeloma are linked to risk factors that can be avoided, meaning there is little you can do to prevent the disease developing. However, being aware of the symptoms may be helpful.
Following a healthy lifestyle, eating a balanced diet and taking regular exercise can reduce your chances of developing many types of cancer.
Meet Our Team
As multiple myeloma can affect many organs of the body, our Multiple Myeloma and Amyloidosis Program consists of a multidisciplinary team of specialists working together to treat all aspects of the disease. Caregivers involved in patient care for this program include:
- Consultant physicians in hematology and oncology
- Pharmacists
- Nurses
- Pathologists
- Radiologists
- Radiation therapists
- Social workers
- Case managers
- Physical therapists
- Infectious diseases specialists
- Cardiologists
- Nephrologists
- Patient coordinators
- Patient educators
Multiple Myeloma and Amyloidosis Program Doctors
Meet the doctors who can help with Multiple Myeloma and Amyloidosis.

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