Cellular Food Intolerance Testing Using Endomicroscopy

What is cellular food intolerance testing using endomicroscopy?
Cellular food intolerance testing using endomicroscopy is an advanced diagnostic procedure that uses high-resolution imaging technology to look at how cells in the lining of the small intestine respond to certain foods in real time.
The innovative food intolerance test is performed during an upper gastrointestinal (GI) endoscopy – a procedure in which a thin, flexible tube with a camera is inserted through your mouth and into your upper digestive tract.
During the test, selected particles of food are introduced directly into the small intestine. Advanced imaging allows doctors to see microscopic changes in the cells lining the small intestine that may indicate food intolerance.
The test gives detailed information about how your body responds to certain foods and allows doctors to make personalized dietary recommendations.
When is cellular food intolerance testing using endomicroscopy performed?
Many people experience food intolerances and ongoing digestive symptoms, and it can be difficult to identify the exact trigger.
Cellular food intolerance testing using endomicroscopy may be performed when ongoing digestive symptoms are experienced, such as:
- Abdominal pain
- Bloating
- Diarrhea
- Discomfort after eating certain foods.
Advanced cellular food intolerance testing can help identify foods that may be causing these symptoms, allowing a more targeted approach to managing your diet.
How does cellular food intolerance testing using endomicroscopy work?
The test is performed during an upper GI endoscopy. You will be given a sedative first to help you relax, then a long, thin tube with a camera is passed gently into your mouth and down your throat into your upper digestive tract.
Particles of carefully selected food are then introduced directly onto the lining of your small intestine via the endoscope.
Endomicroscopy is then used to observe how your body responds. An advanced imaging system allows doctors to see microscopic changes to the cells in the lining of the small intestine. The changes are viewed in real time as you are exposed to the foods.
How should I prepare for cellular food intolerance testing?
Before the procedure, you will be given specific instructions that must be followed carefully. These may include following a special hypoallergenic diet for up to two weeks before the test and fasting for 8 hours before the procedure. You may be given additional instructions based on your individual needs.
What happens after cellular food intolerance testing?
Recovery is usually quick and you will be able to eat as soon as your doctor says it is safe to do so.
Your results will be discussed with you in detail and will be used to develop personalized dietary recommendations and a long-term food management plan.
What are the benefits of cellular food intolerance testing using endomicroscopy?
Cellular food intolerance testing using endomicroscopy is an advanced, precise test used to diagnose food intolerances and chronic gastrointestinal symptoms. Benefits may include:
- Identifying exact food triggers: With real-time visualization of cellular responses to specific foods, it can help to identify foods that trigger symptoms.
- Personalized dietary guidance: The results of the test can guide individualized dietary recommendations based on your body’s response.
- Reduced ‘trial-and-error’ approach: The test may provide more direct evidence of food intolerance for people who have experienced long-term symptoms despite previous evaluations.
- Improved quality of life: By identifying triggers, symptoms can be reduced and digestive health improved.
How is cellular food intolerance testing using endomicroscopy different from allergy testing?
A food allergy is an immune response to a specific food, and causes symptoms such as hives, swelling, breathing difficulties, vomiting, and in severe cases, anaphylaxis. Food allergy testing typically involves assessing immune response.
Food intolerance is when your body has difficulty processing certain foods and is usually associated with digestive symptoms.
Who may benefit from cellular food intolerance testing using endomicroscopy?
People who have ongoing gastrointestinal symptoms associated with food may benefit from cellular food intolerance testing using endomicroscopy.
Your doctor will discuss your symptoms, medical history and any previous investigations and dietary changes, to determine whether this test is appropriate for you.
Always discuss any persistent or new digestive symptoms with your doctor, including:
- Blood in your stool
- Difficulty swallowing
- Ongoing diarrhea
- Persistent vomiting
- Severe abdominal pain
- Unexplained weight loss.

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This page has been reviewed by a medical professional from Cleveland Clinic Abu Dhabi. Information on this page is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition.
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