Headache pain may need to be managed with medications. Medications used to treat headache pain can be grouped into three different types:
Each type of medication is most effective when used in combination with other recommendations, such as dietary modifications, lifestyle changes (at least 7-8 hours of sleep and adequate hydration [6-8 glasses of water/day], exercise and relaxation therapy).
This group of medications is given for the relief of symptoms associated with headache. This includes the pain associated with headaches or nausea and vomiting associated with migraine headaches. Many of the medications are available over-the-counter (without a prescription). Other medications require a prescription from your doctor. When taking these medications, avoid caffeine-containing foods and beverages and medications. Medications containing barbiturates (butalbital) or narcotics (codeine) should be avoided if possible. The use of aspirin should be avoided in children. Many of the medications listed for symptomatic relief are not recommended for use in young children (see end of document for discussion of ‘off-label’ use.)
*Not recommended in pediatric patients
**Nonsteroidal inflammatory drugs
NOTE: For people using symptomatic relief more than twice a week, daily preventive therapy may be considered by your doctor. In addition, appropriate non-medicinal therapy, such as exercise, biofeedback, adequate sleep (at least 8 hours/night), adequate hydration (6 to 8 glasses of water/day), and diet can be used to decrease the frequency of headache attacks, eliminating the need for frequent pain medicines.
These medications are used early in a migraine headache to stop the process that causes the headache pain. In this way, they help minimize the symptoms of headache, such as nausea/vomiting and sound and light sensitivity. These medications are most effective if used at the first sign of a migraine. Some medications should not be used during a migraine aura; please follow the instructions of your doctor.
When headaches—and especially migraine headaches last longer than 24 hours and other medications have been unsuccessful in managing the attacks, medication administered in an “infusion suite” can be considered. An infusion suite is a designated set of rooms at a hospital or clinic that are monitored by a nurse and where intravenous drugs are administered. The intravenous drugs are usually able to end the migraine attack. Patients’ length of stay at the infusion suite can range from several hours to all day.
Use of abortive therapies has not been approved for children (see end of document for discussion of ‘off-label’ use).
*short-acting †= long-acting $ = FDA approved for teens ages 12 to 18
People who are prone to having headaches may develop a pattern of daily or almost-daily headaches. In some people, migraine-type headache attacks may become so frequent that they finally blend together with no clear-cut beginning or end. In both of these cases, the development of more severe or frequent headaches may actually be caused from taking headache relief medications too frequently. Daily or almost daily use of over-the-counter medications such as aspirin, acetaminophen, ibuprofen, narcotics, barbiturates and caffeine-containing medications; or prescription medications such as the triptans, appears to interfere with the brain centers that regulate the flow of pain messages to the nervous system and may make your headache worse. In addition, overmedicating interferes with the effectiveness of prescribed preventive medications.
Rebound headaches may result from taking prescription or nonprescription pain relievers more than two days a week. If prescription or nonprescription abortives are overused, the headaches may rebound as the last dose wears off, leading you to take more and more medication and actually aggravate the pain. When the medications are no longer taken, headache pain will likely improve over a period of 6 to 12 weeks.
These medications are taken daily to prevent headaches. Some of these medications are used for other medical conditions and were accidentally discovered to help headache. While none of these medications cures headache, preventive medications may reduce the frequency, duration and severity of headache attacks.
The medications listed include both over-the-counter and prescription drugs. These drugs are not habit-forming, but any medication can cause unwanted side effects. Your doctor will work with you to carefully regulate the dosage so that side effects are minimized and headache relief is maximized.
To be effective, all preventive medications must be taken one or more times every day. It may be necessary to change the medications and modify their dosages in order to discover which medication or combination of medications, at which dosages, work best to reduce the frequency and severity of your headache pain.
While these medications are being used, carefully recording your headache frequency and severity on a daily basis will help your doctor judge how the medications are working. Most of these medications require days to weeks of daily use before they become fully effective in preventing headaches. A trial of about 8 weeks is recommended before the effectiveness of a medication can be judged by your doctor.
Once good headache control has been achieved and maintained for 6 months or a year, it may be possible to taper and stop these medications. In other cases, it may be necessary to take the medications for a longer period of time.
Preventive therapies have not been approved for use in children. (see end of document for discussion of ‘off label’ use).
*Other SSRIs include citalopram (Celexa®), escitalopram (Lexapro®), fluvoxamine (Luvox®), paroxetine (Paxil®), sertraline (Zoloft®)
Many of the medications listed in this handout have not been approved by the Food and Drug Administration (FDA) for use in children and adolescents with headaches. When a doctor chooses to prescribe a drug for a medical condition or for a certain patient type (eg, children) for which it has not received FDA approval, this practice is called ‘off-label’ prescribing. This is a common practice in the field of medicine. It is one of the ways by which new and important uses are found for already approved drugs. Many times, positive findings lead to formal clinical trials of the drug for new conditions other than what the drug was first approved for.
Many of the drugs prescribed to help prevent head pain disorders are prescribed in this off-label fashion. Please check with your doctor regarding other medications not mentioned in this handout or if you have any concerns or questions.
Pain medications that are least likely to be habit-forming should be tried first. In general, narcotic analgesics are not used in children and adolescents or adults. In all but the most severe headaches, the lowest strength dose should be tried first. Caution should always be used when taking “stronger” medications, because the more frequently the medication is taken, the greater the possibility that they could become harmful and less effective.
Nonprescription pain relievers have been demonstrated to be safe when used as directed. In addition, keep the following precautions in mind:
© Copyright 1995-2018 The Cleveland Clinic Foundation. All rights reserved.
This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or healthcare provider. Please consult your healthcare provider for advice about a specific medical condition.
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