Although acne is essentially a normal physiologic (biological) occurrence, certain conditions might make the disease worse, including the following:

• For women, changing hormone levels around the time of menses (periods)
  
• Manipulating (picking/prodding) acne lesions
• Clothing and headgear that covers a part of the body, such as hats and sports helmets
• Air pollution and certain weather conditions, especially high humidity
  

Only three medicines have proven to be effective for the treatment of acne: benzoyl peroxide, retinoids, and antibiotics. Most patients require at least one or two agents, depending on how severe the disease is.

• Benzoyl peroxide is available as an over-the-counter and by prescription (such as Benzac® or Panoxyl®). It targets surface bacteria, which often aggravate acne. Irritation (dryness) is a common side effect.
• Retinoids (vitamin A derivatives), such as Retin-A®, Differin®, and Tazorac®, are comedolytic, meaning they lyse (break up) comedones (blackheads and whiteheads), the first lesions of acne. Most patients are candidates for retinoid therapy. The most common side effect is irritation.
  
• Antibiotics, either topically applied to the skin (clindamycin, erythromycin) or taken orally (tetracycline and its derivatives) control surface bacteria that aggravate and often foster acne. Antibiotics are more effective when combined with benzoyl peroxide or retinoids.
  

The oral retinoid isotretinoin (Roaccutane®) is reserved for those patients with severe (nodular or cystic) acne. Roaccutane shrinks the size of oil glands, which is where acne begins. Without active, plump oil glands, acne actively decreases.

Side effects of Roaccutane® can be worrisome (dry skin, elevated lipids) and even devastating (birth defects). Women of childbearing age must practice birth control before and during treatment with Roaccutane, and for several months afterward (often a year). The use of Roaccutane® requires rigorous testing (lipids, pregnancy) and follow-up for the prescribed period (five months).

Hormone therapy might be helpful for some women with acne, especially for women who have signs and symptoms (irregular periods, thinning hair) of too much androgen (male hormone). The hormone therapy consists of low-dose estrogen and progesterone (birth control pills) or hormone-blocking agents such as spironolactone.